The WinStar World Resort is the largest casino in the United States. Being in a remote area and sort of off the radar, the WinStar has snuck up on the folks who cover the United States gambling market, and who direct their focus on Vegas, Atlantic City, and the growing Pennsylvania casino market. The United States is home to some 1,500 casinos scattered from coast to coast, more than any other nation on the planet. USA TODAY 10Best teamed up with a panel of casino and gambling experts to ... Your Complete Guide to US Gambling Ages by State ... Local casinos. Casino gambling is heavily regulated in the United States, meaning all casinos and sportsbooks are subject to tons of oversight ... Foxwoods is the 2nd largest casino in the United States. That being the case, the largest casino in the U.S. is the WinStar World Casino Resort in Thackerville, Oklahoma. The massive resort just north of the Texas border has just under 400,000 square feet of gaming space. THE Tusk Rio Casino Resort. The Tusk Rio Casino Resort is located in Klerksdorp, South Africa. Though it is smaller than some its giant counterparts on our list, it still clocks in as one of the top 10 largest casinos in the world.